/* Chocolate melting effect */
.info-card{
    transform: translateY(-70px);
}
.chocolate-card .chocolate-key-card {
  position: relative;
  overflow: hidden;
}

.chocolate-container-inline {
  display: inline-block;
  position: relative;
  margin-left: 10px;
  vertical-align: middle;
}

.chocolate-solid {
  font-size: 1.5rem;
  transition: all 0.8s ease;
  cursor: pointer;
  display: inline-block;
}

.chocolate-melted {
  position: absolute;
  top: 25px;
  left: 5px;
  width: 20px;
  height: 6px;
  background: linear-gradient(45deg, #8B4513, #D2691E, #CD853F);
  border-radius: 50%;
  opacity: 0;
  transform: scaleX(0);
  transition: all 0.8s ease;
}

.chocolate-card:hover .chocolate-solid {
  transform: scale(0.8) rotate(10deg);
  opacity: 0.7;
}

.chocolate-card:hover .chocolate-melted {
  opacity: 1;
  transform: scaleX(1);
  animation: melt 1.5s ease-in-out;
}

@keyframes melt {
  0% { transform: scaleX(0); opacity: 0; }
  50% { transform: scaleX(0.8); opacity: 0.8; }
  100% { transform: scaleX(1); opacity: 1; }
}

/* Chocolate key animation */
.chocolate-key-container {
  display: inline-block;
  position: relative;
  margin-left: 15px;
  left: 10px;
  top: 10px;
  vertical-align: middle;
}



.key-symbol {
  font-size: 2.5rem;
  position: relative;
  z-index: 0;
  transition: all 0.8s ease;
  left: -30px;
  top: -18px;
  transform: rotate(220deg)
}

.chocolate-wrapper {
  position: absolute;
  top: -5px;
  left: -9px;
  font-size: 1.8rem;
  z-index: 3;
  transition: all 0.8s ease;
  opacity: 0.9;
}

.melted-chocolate {
  position: absolute;
  top: 20px;
  left: 0px;
  width: 25px;
  height: 8px;
  background: linear-gradient(45deg, #8B4513, #D2691E, #CD853F);
  border-radius: 50%;
  opacity: 0;
  transform: scaleX(0);
  transition: all 0.8s ease;
  z-index: 1;
}

.chocolate-key-card:hover .chocolate-wrapper {
  transform: scale(0.7) rotate(15deg);
  opacity: 0.3;
}



.chocolate-key-card:hover .melted-chocolate {
  opacity: 1;
  transform: scaleX(1);
  animation: keyMelt 1.8s ease-in-out;
}



/* Comparison table styling */
        .comparison-table {
            background: linear-gradient(135deg, #fef2f2 0%, #fecaca 100%);
            border-radius: 12px;
            padding: 2rem;
            margin: 2rem 0;
            box-shadow: 0 4px 6px rgba(0, 0, 0, 0.1);
        }

        .comparison-header {
            text-align: center;
            margin-bottom: 2rem;
        }

        .comparison-header h3 {
            color: #2d3748;
            font-size: 1.5rem;
            margin-bottom: 0.5rem;
        }

        .comparison-grid {
            display: grid;
            grid-template-columns: 1fr auto 1fr;
            gap: 2rem;
            align-items: start;
        }

        .comparison-column {
            background: white;
            border-radius: 8px;
            padding: 1.5rem;
            box-shadow: 0 2px 4px rgba(0, 0, 0, 0.1);
        }

        .before-column {
            border-left: 4px solid #dc2626;
        }

        .after-column {
            border-left: 4px solid #16a34a;
        }

        .column-header {
            text-align: center;
            margin-bottom: 1.5rem;
            padding-bottom: 1rem;
            border-bottom: 2px solid #fecaca;
        }

        .before-header h4 {
            color: #dc2626;
            margin-bottom: 0.25rem;
        }

        .after-header h4 {
            color: #16a34a;
            margin-bottom: 0.25rem;
        }

        .subtitle {
            font-size: 0.875rem;
            color: #991b1b;
            font-style: italic;
        }

        .comparison-item {
            margin-bottom: 1rem;
            padding: 0.75rem;
            background: #fef2f2;
            border-radius: 6px;
            border-left: 3px solid #fecaca;
        }

        .item-label {
            font-weight: 600;
            color: #7f1d1d;
            font-size: 0.875rem;
            margin-bottom: 0.25rem;
        }

        .item-content {
            color: #2d3748;
            font-size: 0.9rem;
            line-height: 1.4;
        }

        .comparison-arrow {
            display: flex;
            flex-direction: column;
            align-items: center;
            justify-content: center;
            padding: 1rem 0;
        }

        .arrow-symbol {
            font-size: 2rem;
            color: #dc2626;
            margin-bottom: 0.5rem;
            animation: pulse 2s infinite;
        }

        .arrow-label {
            font-weight: 600;
            color: #dc2626;
            font-size: 0.875rem;
            text-align: center;
            writing-mode: vertical-rl;
            text-orientation: mixed;
        }

        @keyframes pulse {
            0%, 100% { transform: scale(1); opacity: 1; }
            50% { transform: scale(1.1); opacity: 0.8; }
        }

        .paradigm-shift {
            margin-top: 2rem;
            padding: 1.5rem;
            background: linear-gradient(135deg, #dc2626 0%, #991b1b 100%);
            color: white;
            border-radius: 8px;
            text-align: center;
        }

        .paradigm-shift h4 {
            color: white;
            margin-bottom: 1rem;
        }

        .paradigm-shift p {
            line-height: 1.6;
            opacity: 0.95;
        }

        /* Equation and code styling */
        .code-text {
            font-family: 'Courier New', monospace;
            background: #fef2f2;
            padding: 2px 6px;
            border-radius: 4px;
            font-size: 0.9rem;
            color: #7f1d1d;
        }

        .equation {
            font-family: 'Times New Roman', serif;
            font-style: italic;
            color: #dc2626;
            font-weight: 500;
        }

        .equation-large {
            font-family: 'Times New Roman', serif;
            font-style: italic;
            color: #dc2626;
            font-weight: 600;
            font-size: 1.1rem;
        }

        .equation-center {
            text-align: center;
            margin: 1.5rem 0;
            padding: 1rem;
            background: #fef2f2;
            border-radius: 8px;
            border-left: 4px solid #dc2626;
        }

        .equation-box {
            background: #fef2f2;
            border-radius: 8px;
            padding: 1.5rem;
            margin: 1.5rem 0;
            border-left: 4px solid #991b1b;
        }

        .equation-list {
            list-style: none;
            padding: 0;
            margin: 0;
        }

        .equation-list li {
            margin-bottom: 1rem;
            padding: 0.75rem;
            background: white;
            border-radius: 6px;
            border-left: 3px solid #fecaca;
        }

        .highlight-equation {
            background: linear-gradient(135deg, #fef3c7, #fde68a);
            padding: 0.5rem 1rem;
            border-radius: 6px;
            color: #92400e;
            font-weight: 700;
        }

        .recommendation-box {
            background: linear-gradient(135deg, #fee2e2, #fecaca);
            border-radius: 8px;
            padding: 1.5rem;
            margin: 1.5rem 0;
            border-left: 4px solid #dc2626;
        }

        .recommendation-box h4 {
            color: #991b1b;
            margin-bottom: 1rem;
            font-size: 1.1rem;
        }

        .recommendation-box p {
            margin-bottom: 0.75rem;
            color: #7f1d1d;
            line-height: 1.5;
        }

        .example-box {
            background: linear-gradient(135deg, #f0fdf4, #dcfce7);
            border-radius: 8px;
            padding: 1.5rem;
            margin: 1.5rem 0;
            border-left: 4px solid #16a34a;
        }

        .example-box h4 {
            color: #15803d;
            margin-bottom: 1rem;
            font-size: 1.1rem;
        }

        .example-box p {
            margin-bottom: 0.75rem;
            color: #166534;
            line-height: 1.5;
        }

        .example-box ul {
            color: #166534;
        }

        /* Aptamer comparison table */
        .aptamer-table {
            background: white;
            border-radius: 8px;
            overflow: hidden;
            box-shadow: 0 2px 4px rgba(0, 0, 0, 0.1);
            margin: 2rem 0;
        }

        .aptamer-table table {
            width: 100%;
            border-collapse: collapse;
        }

        .aptamer-table th {
            background: #dc2626;
            color: white;
            padding: 1rem;
            text-align: left;
            font-weight: 600;
        }

        .aptamer-table td {
            padding: 0.75rem 1rem;
            border-bottom: 1px solid #fecaca;
            vertical-align: top;
        }

        .aptamer-table tr:nth-child(even) {
            background: #fef2f2;
        }

        .decision-accepted {
            background: #dcfce7;
            color: #15803d;
            padding: 0.25rem 0.5rem;
            border-radius: 4px;
            font-weight: 600;
        }

        .decision-rejected {
            background: #fee2e2;
            color: #dc2626;
            padding: 0.25rem 0.5rem;
            border-radius: 4px;
            font-weight: 600;
        }

        .decision-possible {
            background: #fef3c7;
            color: #92400e;
            padding: 0.25rem 0.5rem;
            border-radius: 4px;
            font-weight: 600;
        }

        /* Linker analysis styling */
        .linker-analysis {
            background: linear-gradient(135deg, #fef2f2 0%, #fee2e2 100%);
            border-radius: 12px;
            padding: 2rem;
            margin: 2rem 0;
            border-left: 4px solid #dc2626;
        }

        .linker-grid {
            display: grid;
            grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
            gap: 1.5rem;
            margin: 1.5rem 0;
        }

        .linker-card {
            background: white;
            border-radius: 8px;
            padding: 1.5rem;
            box-shadow: 0 2px 4px rgba(0, 0, 0, 0.1);
            border-top: 4px solid #dc2626;
        }

        .linker-card h4 {
            color: #dc2626;
            margin-bottom: 1rem;
            font-size: 1.1rem;
        }

        .linker-property {
            margin-bottom: 0.75rem;
            padding: 0.5rem;
            background: #fef2f2;
            border-radius: 4px;
            border-left: 3px solid #fecaca;
        }

        .property-label {
            font-weight: 600;
            color: #7f1d1d;
            font-size: 0.875rem;
        }

        .property-value {
            color: #2d3748;
            font-size: 0.9rem;
            margin-top: 0.25rem;
        }

        /* Responsive design */
        @media (max-width: 768px) {
            .page-container {
                flex-direction: column;
            }
            
            .sidebar {
                width: 100%;
                height: auto;
                position: static;
            }
            
            .comparison-grid {
                grid-template-columns: 1fr;
                gap: 1rem;
            }
            
            .comparison-arrow {
                order: 2;
                flex-direction: row;
                padding: 0.5rem;
            }
            
            .arrow-symbol {
                transform: rotate(90deg);
                margin: 0 0.5rem;
            }
            
            .arrow-label {
                writing-mode: horizontal-tb;
                text-orientation: initial;
            }
            
            .before-column {
                order: 1;
            }
            
            .after-column {
                order: 3;
            }
            
            .equation-large {
                font-size: 1rem;
            }
            
            .equation-center {
                padding: 0.75rem;
            }

            .linker-grid {
                grid-template-columns: 1fr;
            }

            .aptamer-table {
                overflow-x: auto;
            }
        }