Problem
Solution
Our aim
Problem
Celiac disease is a chronic autoimmune disorder that is triggered by the ingestion of gluten, a protein naturally
found in wheat, barley, and rye. A specific component of gluten, known as gliadin, cannot be fully broken down by
human digestive enzymes. In individuals with celiac disease, fragments of gliadin are mistakenly identified as
harmful by the immune system, prompting an inflammatory response driven by T-cells. This immune reaction can lead
to a wide range of symptoms, including abdominal pain, fatigue, and in some cases, hospital visits due to more
severe complications.
Approximately 1 of 114 Canadians are affected by Celiac disease. Currently, the only effective treatment is a
strict gluten-free diet. While this approach allows individuals to manage their symptoms, it does not eliminate
the risk of accidental gluten exposure due to cross-contamination.
Solution
Our team is developing an approach centered around engineered probiotic bacteria capable of secreting gluten-degrading enzymes directly in the gut. We aim to efficiently deliver enzymes that
have been shown to break down the immunogenic peptides responsible for triggering the immune response in individuals with celiac disease. In parallel, we investigated peptide caps
that can bind to residual gliadin fragments, masking the key epitopes and preventing the immune system from recognizing uncleaved gluten.
Together, these strategies highlight complementary ways to significantly reduce the concentration of harmful gluten fragments before they can activate the immune system, offering a potential layer of protection beyond the limitations of a gluten-free diet.
For more information on our solution, visit our Project Description page!
Our Aim
By providing a practical way to prevent accidental gluten exposure, this work has the potential to significantly improve the daily lives of people with celiac disease. Beyond individual health, it demonstrates how innovative biotechnological approaches can be translate into meaningful clinical solutions, offering greater independence, safety, and peace of mind for those managing strict dietary restrictions.
