With limited options for reimbursable drugs in the pet sector, pet owners are under considerable economic strain. Meanwhile, the overuse of antibiotics has fostered bacterial drug resistance, and when combined with drug-resistant bacterial infections, it makes pets highly susceptible to bacterial infections after injury. This not only prolongs the treatment cycle and drives up treatment costs but can even lead to pet deaths in severe cases.
Low tendency to induce drug resistance
Rapid onset of action
Broad-spectrum antibacterial activity
Effective against multidrug-resistant bacteria
Good biocompatibility & low residue
Wide sources & synthetic accessibility
Cationic AMPs interact with bacterial membrane, forming pores to kill bacteria.
AMPs penetrate bacterial membrane to target cellular processes.
Some AMPs penetrate via self-promoted uptake, targeting key processes.
Mammalian membranes resist AMPs due to zwitterionic phospholipids and cholesterol.
