About Helicobacter pylori
Fifty percent of people worldwide have been infected with Helicobacter pylori, one of the most infected bacteria in the world!
The Pathogenic Role of Urease in Helicobacter pylori
* Direct Host Cell Damage
* Acid Resistance (Essential for Colonization)
* Maintenance of Chronic Infection
Precautions:
* Pay attention to personal hygiene (e.g. wash hands before and after eating, avoid sharing personal items)
* Pay attention to dietary safety (e.g. avoid raw foods, drink unboiled water)
* Be careful with child protection (e.g. avoid mouth-to-mouth feeding)
Our Team
We are an iGEM team composed of a group of high school students. By constructing a gene expression system for recombinant nanobodies specifically targeting the Helicobacter pylori (Hp) urease subunit (UreB) and exploring their expression in food-grade probiotics, we aim to enable direct and precise prevention and control of Hp through live bacterial administration. This study lays a solid foundation for the development of immunotherapy against Hp, demonstrating strong innovation and significant application potential.
