.assumptions-timeline {
    max-width: 900px;
    margin: 0 auto;
    padding: 2rem 1rem;
  }
  
  .assumptions-intro {
    color: #efe1d2;
    margin-bottom: 2rem;
  }
  
  .timeline {
    position: relative;
   /* border-left: 4px solid #be9a67;*/
    padding-left: 2rem;
  }
  
  .timeline-step {
    position: relative;
    margin-bottom: 2rem;
  }
  
  .timeline-marker {
    position: absolute;
    left: -2.1rem;
    top: 0;
    width: 32px;
    height: 32px;
    border-radius: 50%;
    background: #be9a67;
    color: #fff;
    font-weight: 700;
    display: flex;
    align-items: center;
    justify-content: center;
    box-shadow: 0 0 6px rgba(0,0,0,.2);
  }
  
  .timeline-content h3 {
    margin: 0 0 .5rem 0;
    color: #e5d49c;
  }
  
  .timeline-content p {
    color: #efe1d2;
    line-height: 1.55;
  }
  
  .sirbench-spec { max-width: 1100px; margin: 0 auto; padding: 2rem 1rem; }
  .spec-intro { color: #efe1d2; margin-bottom: 1.5rem; }
  
  
  .rules-box {
    background: #001028;
    border: 1px solid rgba(255,255,255,.15);
    border-radius: 12px;
    padding: 1rem 1.2rem;
    margin-top: .5rem;
  }
  .rules-box h3 { margin: 0 0 .5rem 0; color: #e5d49c; }
  
  .checklist { list-style: none; padding: 0; margin: 0; }
  .checklist li { color: #efe1d2; margin: .5rem 0; line-height: 1.5; display: flex; gap: .6rem; }
  .checklist li span {
    display: inline-flex; align-items: center; justify-content: center;
    width: 22px; height: 22px; border-radius: 50%;
    background: #be9a67; color: #fff; font-weight: 700; flex: 0 0 22px;
  }
  
  .schema-preview { margin-top: 1rem; }
  .schema-preview summary { cursor: pointer; color: #be9a67; }
  .schema-preview pre {
    margin-top: .6rem; padding: .8rem 1rem; overflow: auto;
    background: #0a1320; color: #efe1d2; border: 1px solid #be9a67; border-radius: 8px;
    font-size: .9rem;
  }
  
  .sirbench-timeline {
    max-width: 900px;
    margin: 0 auto;
    padding: 2rem 1rem;
  }
  
  .timeline {
    position: relative;
    border-left: 4px solid #be9a67;
    padding-left: 2rem;
  }
  
  .timeline-step {
    position: relative;
    margin-bottom: 2rem;
  }
  
  .timeline-marker {
    position: absolute;
    left: -2.1rem;
    top: 0;
    width: 32px;
    height: 32px;
    border-radius: 50%;
    background: #be9a67;
    color: #fff;
    font-weight: 700;
    display: flex;
    align-items: center;
    justify-content: center;
    box-shadow: 0 0 6px rgba(0,0,0,.2);
  }
  
  .timeline-content h3 {
    margin: 0 0 .5rem 0;
    color: #e5d49c;
  }
  
  .timeline-content ul {
    margin: 0;
    padding-left: 1.2rem;
    color: #efe1d2;
    line-height: 1.6;
  }
  
  /* siRNA Roadmap Vertical */
  
  .sirna-roadmap-vertical {
    max-width: 800px;
    margin: 0 auto;
    padding: 2rem 1rem;
  }
  
  .roadmap-intro {
    color: #efe1d2;
    margin-bottom: 2rem;
  }
  
  .roadmap-vertical {
    display: flex;
    flex-direction: column;
    gap: 2rem;
    position: relative;
  }
  
  .vstep {
    position: relative;
    background: #e5d49c;
    border: 2px solid #be9a67;
    border-radius: 12px;
    padding: 1rem 1.2rem 1.2rem 3.5rem;
    box-shadow: 0 4px 12px rgba(0,0,0,.1);
  }
  
  .vstep-head {
    display: flex;
    align-items: center;
    gap: .6rem;
    margin-bottom: .4rem;
  }
  
  .vbadge {
    position: absolute;
    left: 1rem;
    top: 1rem;
    display: flex; align-items: center; justify-content: center;
    width: 32px; height: 32px;
    border-radius: 50%;
    background: #be9a67;
    color: #fff;
    font-weight: 700;
    box-shadow: 0 0 6px rgba(0,0,0,.2);
  }
  
  .vstep h3 {
    margin: 0;
    color: #001028;
    font-size: 1.1rem;
  }
  
  .vstep p {
    color: #2b2b2b;
    line-height: 1.55;
    margin: 0;
  }
  
  /* Connector arrows */
  .vstep::after {
    content:"";
    position: absolute;
    left: 50%;
    bottom: -24px;
    transform: translateX(-50%);
    border-left: 14px solid transparent;
    border-right: 14px solid transparent;
    border-top: 14px solid #be9a67;   /* border color */
    z-index: 2;
  }
  .vstep::before {
    content:"";
    position: absolute;
    left: 50%;
    bottom: -22px;
    transform: translateX(-50%);
    border-left: 12px solid transparent;
    border-right: 12px solid transparent;
    border-top: 12px solid #e5d49c;   /* fill color */
    z-index: 3;
  }
  
  /* Remove connector from last step */
  .vstep:last-child::after,
  .vstep:last-child::before {
    display: none;
  }
  
  .sirna-codes { max-width: 900px; margin: 0 auto; padding: 2rem 1rem; }
  
  .codes-intro, .codes-outro { color: #efe1d2; max-width: 800px; margin: 0 auto 1rem; }
  
  .codes-legend {
    background: #e5d49c;
    border: 2px solid #be9a67;
    border-radius: 12px;
    padding: 1rem 1.25rem;
    box-shadow: 0 4px 12px rgba(0,0,0,.12);
  }
  
  .code-item {
    display: flex; gap: .75rem; align-items: flex-start;
    padding: .5rem 0;
    border-bottom: 1px dashed rgba(0,0,0,.15);
  }
  .code-item:last-child { border-bottom: 0; }
  
  .badge {
    display:inline-flex; align-items:center; justify-content:center;
    width: 28px; height: 28px; border-radius: 50%;
    color:#fff; font-weight:700; flex: 0 0 28px;
    box-shadow: 0 0 6px rgba(0,0,0,.18);
  }
  .badge-e { background: #2f855a; }   /* validated */
  .badge-d { background: #be9a67; }   /* designed in-house */
  
  .codes-legend p { margin: 0; color: #2b2b2b; line-height: 1.55; }
  .codes-legend strong { color: #001028; }
  
  .codes-examples {
    margin-top: 1rem;
    background: #001028;
    border: 1px solid rgba(255,255,255,.15);
    border-radius: 10px;
    padding: .9rem 1rem;
  }
  .codes-examples h3 { margin: 0 0 .5rem 0; color: #e5d49c; }
  .codes-examples ul { margin: 0; padding-left: 1rem; color: #efe1d2; }
  .codes-examples li { margin-bottom: .35rem; display: flex; align-items: center; gap: .5rem; }
  
  .sirbench-dataset {
    max-width: 1100px;
    margin: 0 auto;
    padding: 2rem 1rem;
  }
  
  .dataset-intro p {
    color: #efe1d2;
    line-height: 1.6;
    margin-bottom: 2rem;
  }
  
  .dataset-card {
    background: #e5d49c;
    border: 2px solid #be9a67;
    border-radius: 12px;
    padding: 1.25rem 1.5rem;
    margin-bottom: 1.5rem;
    box-shadow: 0 4px 12px rgba(0,0,0,.1);
  }
  
  .dataset-card h3 {
    margin-top: 0;
    color: #001028;
  }
  
  .dataset-card p,
  .dataset-card ul {
    color: #2b2b2b;
    line-height: 1.55;
  }
  
  .dataset-card ul { padding-left: 1.2rem; margin-top: .5rem; }
  
  .dataset-table {
    width: 100%;
    border-collapse: collapse;
    margin-top: 1rem;
  }
  
  .dataset-table th,
  .dataset-table td {
    border: 2px solid #be9a67;
    padding: .6rem .8rem;
    text-align: left;
    vertical-align: top;
  }
  
  .dataset-table th {
    background: #be9a67;
    color: #fff;
  }
  
  .dataset-table td {
    background: #001028;
    color: #efe1d2;
  }
  
  
  .feature-engineering {
    max-width: 1000px;
    margin: 0 auto;
    padding: 2rem 1rem;
  }
  
  .fe-card {
    background: #e5d49c;
    border: 2px solid #be9a67;
    border-radius: 12px;
    padding: 1.25rem 1.5rem;
    margin-bottom: 1.5rem;
    box-shadow: 0 4px 12px rgba(0,0,0,.1);
  }
  
  .fe-card h3 {
    margin-top: 0;
    color: #001028;
    margin-bottom: .5rem;
  }
  
  .fe-card p {
    color: #2b2b2b;
    line-height: 1.55;
  }
  
  .feature-list {
    margin: 0;
    padding-left: 1.2rem;
    color: #2b2b2b;
    line-height: 1.55;
  }
  
  .feature-list li {
    margin-bottom: .45rem;
  }
  
  .model-results {
    max-width: 1000px;
    margin: 0 auto;
    padding: 2rem 1rem;
  }
  
  .result-card {
    background: #e5d49c;
    border: 2px solid #be9a67;
    border-radius: 12px;
    padding: 1.25rem 1.5rem;
    margin-bottom: 1.5rem;
    box-shadow: 0 4px 12px rgba(0,0,0,.1);
  }
  
  .result-card h3 {
    margin-top: 0;
    color: #001028;
  }
  
  .result-card ul {
    margin: 0;
    padding-left: 1.2rem;
    color: #2b2b2b;
    line-height: 1.55;
  }
  
  .result-card ul li {
    margin-bottom: .45rem;
  }
  
  .thermo-modeling {
    max-width: 1000px;
    margin: 0 auto;
    padding: 2rem 1rem;
  }
  
  .thermo-card {
    background: #e5d49c;
    border: 2px solid #be9a67;
    border-radius: 12px;
    padding: 1.25rem 1.5rem;
    margin-bottom: 1.5rem;
    box-shadow: 0 4px 12px rgba(0,0,0,.1);
  }
  
  .thermo-card h3 {
    margin-top: 0;
    color: #001028;
  }
  
  .thermo-card p,
  .thermo-card ul {
    color: #2b2b2b;
    line-height: 1.6;
  }
  
  .thermo-card ul {
    padding-left: 1.2rem;
    margin-top: .5rem;
  }
  .thermo-card li { margin-bottom: .6rem; }
  
  .image-pair {
    display: flex !important;
    flex-direction: row !important;
    justify-content: center !important;
    margin-top: 3vh !important;
    margin-bottom: 8vh !important;
    gap: 5vw !important; /* replaces margin-right */
  }
  
  .image-pair figcaption {
    font-size: 1.26rem !important;
    margin-bottom: -0.69vh;
  }
  
  .model-img {
    height: 45vh !important;
    width: auto !important;
    max-width: 420px !important; /* cap how wide they can get */
    border-radius: 15px !important;
    border: 2px solid #d4af37 !important;
  }
  
  /* Make them stack on small screens */
  @media (max-width: 768px) {
    .image-pair {
      flex-direction: column;
      align-items: center; /* centers them vertically */
      gap: 4vh;
    }
    .model-img {
      height: auto;
      width: 85%; /* make them scale nicely */
      max-width: 500px;
    }
  }
  
  /* Container spacing */
  .siRNA-list {
    list-style: none; /* remove default bullets */
    padding-left: 0;
    margin-top: 2vh;
  }
  
  /* Main category items (BCL2 / BTK) */
  .siRNA-list > li {
    font-weight: 700;
    font-size: 1.2rem;
    color: #efe1d2;
    margin-bottom: 2vh;
    position: relative;
    padding-left: 1.5rem;
  }
  
  /* Custom gold marker for main list */
  .siRNA-list > li::before {
    content: "◆";
    position: absolute;
    left: 0;
    color: #d4af37;
    font-size: 0.9rem;
    top: 0.2rem;
  }
  
  /* Sublist */
  .siRNA-list ul {
    list-style: none; /* remove default bullets */
    margin-top: 1vh;
    padding-left: 1.5rem;
  }
  
  /* Sublist items */
  .siRNA-list ul li {
    font-weight: 400;
    font-size: 1rem;
    color: #be9a67;
    margin-bottom: 0.8vh;
    position: relative;
    padding-left: 1.2rem;
  }
  
  /* Custom round bullet for sublist */
  .siRNA-list ul li::before {
    content: "•";
    position: absolute;
    left: 0;
    color: #d4af37;
    font-size: 1rem;
    top: 0.1rem;
  }
  
  /* Base list container */
  .observations-list {
    list-style: none;
    padding-left: 0;
    margin-top: 2vh;
  }
  
  /* Main category items */
  .observations-list > li {
    margin-bottom: 2.5vh;
    font-size: 1.15rem;
    position: relative;
    color: #d4af37;
    padding-left: 1.5rem;
  }
  
  /* Gold diamond marker */
  .observations-list > li::before {
    content: "◆";
    position: absolute;
    left: 0;
    color: #d4af37;
    font-size: 0.9rem;
    top: 0.35rem;
  }
  
  /* Sublist styling */
  .observations-list ul {
    list-style: none;
    margin-top: 0.8vh;
    padding-left: 1.5rem;
  }
  
  /* Sublist items */
  .observations-list ul li {
    font-weight: 400;
    font-size: 1rem;
    color: #efe1d2;
    margin-bottom: 0.7vh;
    position: relative;
    padding-left: 1.2rem;
  }
  
  /* Gold dot for sublist */
  .observations-list ul li::before {
    content: "•";
    position: absolute;
    left: 0;
    color: #d4af37;
    font-size: 1rem;
    top: 0.2rem;
  }
  
  /*LNP*/
  .lnp-single-grid{
    display:grid;
    grid-template-columns: 1fr;
    gap:16px;
    margin: 12px 0 18px;
  }
  @media (min-width: 980px){
    .lnp-single-grid{ grid-template-columns: 300px 1fr; }
  }
  
  .lnp-panel{
    border:1px solid rgba(212,175,55,0.35);
    border-radius:14px;
    background:rgba(212,175,55,0.06);
    padding:12px;
  }
  .lnp-panel label{ display:block; margin-bottom:6px; }
  #lnpSelect{
    width:100%;
    padding:8px 10px;
    border-radius:10px;
    border:1px solid rgba(212,175,55,0.6);
    background: #d4af37;
    margin-bottom:10px;
    cursor:pointer;
  }
  
  .lnp-toolbar{
    display:flex;
    flex-wrap:wrap;
    gap:8px;
    margin-bottom:10px;
  }
  .lnp-btn{
    border:1px solid rgba(212,175,55,0.6);
    background:rgba(237, 234, 221, 0.847);
    padding:6px 10px;
    border-radius:10px;
    font-size:0.92rem;
    cursor:pointer;
  }
  .lnp-btn:hover{ filter:brightness(1.05); }
  .lnp-toolbar .sep{
    width:1px;height:22px;
    background:rgba(0,0,0,0.15);
    margin:0 4px;
  }
  
  .lnp-label, .lnp-label strong { color: #d4af37; }
  
  .lnp-status{ font-size:0.9rem; color:#efe3e3; min-height:1.2rem; }
  
  .lnp-viewer{
    width:100%;
    height:520px;
    position:relative;
    background:#fff;
    border-radius:10px;
    overflow:hidden;
    border:1px solid rgba(212,175,55,0.25);
  }
  
  /* Dark mode */
  @media (prefers-color-scheme: dark){
    .lnp-panel{ background:rgba(212,175,55,0.10); }
    .lnp-toolbar .sep{ background:rgba(255,255,255,0.2); }
    .lnp-viewer{ background:#000; }
    .lnp-status{ color:#cfcfcf; }
  }
  
  .dataset-advantages {
    max-width: 900px;
    margin: 0 auto;
    padding: 2rem 1rem;
  }
  
  .adv-card {
    background: #e5d49c;
    border: 2px solid #be9a67;
    border-radius: 12px;
    padding: 1.25rem 1.5rem;
    box-shadow: 0 4px 12px rgba(0,0,0,.1);
  }
  
  .adv-card ul {
    margin: 0;
    padding-left: 1.2rem;
    color: #2b2b2b;
    line-height: 1.6;
  }
  
  .structural-modeling {
    max-width: 1100px;
    margin: 0 auto;
    padding: 2rem 1rem;
  }
  
  .intro-text {
    color: #efe1d2;
    text-align: center;
    max-width: 900px;
    margin: 0 auto 2rem auto;
    line-height: 1.6;
  }
  
  .structure-card {
    background: #e5d49c;
    border: 2px solid #be9a67;
    border-radius: 12px;
    padding: 1.25rem 1.5rem;
    margin-bottom: 1.5rem;
    box-shadow: 0 4px 12px rgba(0,0,0,.1);
  }
  
  .structure-card h3 {
    color: #001028;
    margin-top: 0;
    margin-bottom: .5rem;
  }
  
  .structure-card p {
    color: #2b2b2b;
    line-height: 1.55;
  }
  
  .summary-card {
    background: #001028;
    border: 2px solid #be9a67;
    border-radius: 12px;
    padding: 1.25rem 1.5rem;
    color: #efe1d2;
    box-shadow: 0 4px 15px rgba(0,0,0,.2);
  }
  
  .summary-card h3 {
    color: #e5d49c;
    margin-top: 0;
    margin-bottom: .5rem;
  }
  .summary-card p {
    line-height: 1.6;
    color: #efe1d2;
  }