Sepsis is a life-threatening condition caused by the body’s extreme response to an infection.
Microorganisms, such as viruses, fungi and bacteria enter the body.
The immune system fights
the cause of infection with
macrophages secreting cytokines.
A dysregulated response leads to damage in body tissues and organs and even death.
Anatomical illustration of the human body turning,
highlighting key organ systems
Sepsis is one of the most frequent causes of death worldwide.
Each year, sepsis affects around 0 people worldwide and causes 0 deaths.
In other words;
Every minute more than
20 people die of sepsis
1 in 5 deaths globally is due to sepsis
50% of cases involve children under the age of 5
Mothers die of sepsis due to pregnancy-related causes each year
Sepsis occurs when your body’s response to an infection is extreme and therefore damages vital organs and, often, causes death. This infection can be caused by viruses, bacteria , fungi, or parasites.
According to WHO, bacterial infections are the most common causes of sepsis
Sepsis often happens within healthcare settings, as a result of hospital-acquired infections, posing an even greater challenge for patients who are already hospitalized
Current diagnostic methods for sepsis, rely on nonspecific clinical signs
Standard laboratory techniques take 12-72 hours to deliver results.
Yet, every 1 hour delay in diagnosis increases the chance of death by 6–10%.
Existing tools provide no clear prognostic insight into disease severity and patients outcomes
AECHMI is a CRISPR-based biological system designed for rapid, specific, and highly sensitive identification of bacterial sepsis. Beyond diagnosis, AECHMI offers prognostic insight, enabling prediction of patient outcomes.
CRISPR recognizes sepsis-specific circulating microRNA biomarkers
Biomarker recognition triggers the production of an electrochemical signal.
The signal amplifies to
detect and quantify
low levels of biomarkers.
AECHMI is designed to be incorporated into a microneedle–microfluidic device for real time biomarker monitoring in healthcare settings:
Microneedles will gently extract biomarkers directly from the bloodstream, and the resulting samples will undergo rapid reactions as they flow through microfluidic channels
