REv-Design Title

Rational Evolutionary Involved Enzyme ReDesign

Plant natural products are widely applied in the fields of medicine, food, and agriculture.

Heterologous biological manufacturing is an efficient way to obtain plant natural productsbut it is troubled by the reduction in enzyme catalytic activity.

REvoDesign: A more efficient and simplified plant protein design software.

Enzyme Structure
Molecular Design
In 2023, there were 263 million malaria cases worldwide.In 2021, cardiovascular diseases caused 20.5 million deaths, with 330 million patients in China.In 2022, 20 million new cancer cases were reported globally, resulting in 9.7 million deaths.
China's "14th Five-Year Plan for the Development of Bioeconomy" The US "National Biotechnology and Biomanufacturing Initiative The EU's "Biotechnology and
Biomanufacturing"
The global market size of plant extracts was about 18.49 billion
US dollars in 2024. The food
industry is a pillar industry of
China's economy, with an output
value of 90000 billion
yuan in 2024.

Advancing biotechnology, supportive policies, and growing market demand are driving the development and utilization of plant natural products.

Paclitaxel
Cucurbitacin
Artemisnin
Lycopene

Why

Synthetic biology gives new way for their production.

Plant enzymes often show low fitness in microbes.
Low activity and low stability.
REvoDesign solves this bottleneck.

How

A semi-rational transformation workflow and its visualization auxiliary tools based on co-evolution analysis and protein rational design.
· A solution that requires no programming skills.
· Access to multi-model tools for cross-screening.
· Combines functionality and knowledge learning.

Input

Design

Filter & Reduce

Validation & Iteration

Let's start designing your protein!

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