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Number |
Name |
Part type |
Part type |
Part function |
Part diagram |
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HO |
Basic Part |
Coding |
Heme oxygenase is utilized in the breakdown of heme, a process that releases biliverdin, carbon monoxide, and iron. In research and biotechnology, heme oxygenase may be used to study heme metabolism, investigate the effects of heme breakdown products, or develop therapeutic strategies targeting heme-related disorders. Heme oxygenase is a critical enzyme involved in the catabolism of heme, an essential component of hemoglobin and other heme-containing proteins. The expression and regulation of heme oxygenase are tightly controlled in response to cellular heme levels, oxidative stress, and various signaling pathways in the body |
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DrBphP |
Basic Part |
Coding |
DrBphP is utilized as a photoreceptor that can sense red/far-red light and trigger downstream signaling pathways in response to light stimuli. Bacterial phytochromes, such as DrBphP, contain light-absorbing chromophores that undergo conformational changes upon light absorption. DrBphP and related bacterial phytochromes play a role in regulating bacterial physiology in response to environmental light conditions, such as adjusting growth, metabolism, or biofilm formation |
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YF1 |
Basic Part |
Coding |
The YF1 domain is utilized as a sensor domain in two-component signal transduction systems, where it detects specific signals and initiates a signaling cascade. Upon phosphorylation, the HK domain interacts with response regulators to relay signals and regulate gene expression, metabolism, or other cellular processes. YF1 and other effector Histidine Kinase domains play a critical role in cellular adaptation to changing conditions, including osmolarity, light, and nutrient availability |
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FixJ |
Basic Part |
Coding |
FixJ is a response regulator protein that plays a crucial role in certain bacteria, particularly in the process of nitrogen fixation. Typically functioning as a response regulator in two-component signal transduction systems, FixJ interacts with the effector component to modulate gene expression and cellular functionsy |
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λ |
Basic Part |
Coding |
Gene inversion cassette encoding the λ phage cI repressor and the pR promoter-controlled inverter |
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GFP |
Basic Part |
Coding |
GFP is commonly utilized as a fluorescent marker in biological research to visualize and track proteins, cells, and organelles in living systems. It serves as a valuable tool for studying gene expression, protein localization, cell dynamics, and molecular interactions. GFP functions as a reporter protein that emits green fluorescence when exposed to ultraviolet or blue light. The protein's structure includes a chromophore that undergoes autocatalytic reactions to produce the characteristic green fluorescence. GFP has been engineered into numerous variants with different spectral properties, allowing for multicolor labeling and advanced imaging techniques |
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Anti-PD-L1 |
Basic Part |
Coding |
Anti-PD-L1 antibodies are used in cancer immunotherapy to help the immune system recognize and attack cancer cells. By blocking the PD-L1 receptor, these antibodies prevent cancer cells from evading immune detection and enhance the immune response against tumors. The PD-L1 pathway is a key immune checkpoint that regulates the immune response to prevent excessive activation and maintain self-tolerance. Cancer cells can exploit this pathway to suppress the immune system's ability to recognize and destroy them. Anti-PD-L1 antibodies disrupt this immune checkpoint, allowing the immune system to better target and eliminate cancer cells |
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Anti-PD-1 |
Basic Part |
Coding |
Anti-PD-1 antibodies are used in cancer immunotherapy to help the immune system recognize and attack cancer cells. By blocking the PD-1 receptor, these antibodies prevent cancer cells from evading immune detection and enhance the immune response against tumors. The PD-1 pathway is a key immune checkpoint that regulates the immune response to prevent excessive activation and maintain self-tolerance. Cancer cells can exploit this pathway to suppress the immune system's ability to recognize and destroy them. Anti-PD-1 antibodies disrupt this immune checkpoint, allowing the immune system to better target and eliminate cancer cells |
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pRED-Vector |
Basic Part |
Plasmid_Backbone |
A vector can provide a promoter, a replicon, and an antibiotic resistance gene. |
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pRED |
Composite Part |
Plasmid |
A plasmid vector containing a red light inducing system. |
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pRED-GFP |
Composite Part |
Plasmid |
Based on the plasmid vector of red light induction system, a GFP fluorescent protein was introduced. |
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PRED-Anti-PD-L1 |
Composite Part |
Plasmid |
Based on the plasmid vector of red-light induction system, an Anti-PD-L1 antibody protein was introduced. |
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PRED-Anti-PD-1 |
Composite Part |
Plasmid |
Based on the plasmid vector of red-light induction system, an Anti-PD-1 antibody protein was introduced. |
PART COLLECTION
