Antimicrobial Resistance
The silent pandemic of the 21st century – projected to cause up to 10 million annual deaths within the next 30 years.
In this crisis, the ESKAPE pathogens pose the biggest threat to human health.
Endolysins – enzymes derived from bacteriophages – can break down the peptidoglycan layer of bacterial cell walls, causing rapid cell lysis.
Model-guided AMP selection and fusion to enable specific targeting of Gram-negative bacteria with endolysins.
A modular platform for the efficient production and optimization of novel endolysins to combat resistant bacterial infections.
To disrupt biofilm barriers in endolysin application, we combine phage-mediated delivery with antimicrobial and signalling peptides.