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ChronoKolla

CAFA-BEIJING proposes an innovative synthetic biology solution in the medical aesthetic skincare field, advocating for healthy, convenient, efficient, and daily skincare and aesthetic practices. Join us in exploring how to design the future starting today.

Learn more about Chronokolla

A Designer's Journey to Skin Renewal

Workplace Life on the Edge of Collapse

My name is Lucy. As a senior designer, my life has been shattered into fragments by endless deadlines. Each morning begins with a cup of black coffee to power through my fatigue, while the blue glow of the screen has become my most loyal companion. When the office falls silent late at night, leaving only me and the endless revisions, milk tea and desserts are my only comfort.

This lifestyle has wreaked havoc on my skin: long hours of sitting made me overweight while leaving my face loose and sagging. Even worse, the sleepless nights caused dark spots to spread across my cheeks like spilled ink, and every glance in the mirror felt suffocating.

I turned to medical beauty treatments, but ironically, they drained nearly all of my income while offering results far too infrequent. At the same time, they squeezed my already limited work hours even tighter.

The Turning Point Brought by Technology

Just when I was on the verge of giving up, a chance encounter introduced me to this project. The most remarkable part is that its solution doesn’t require me to change my lifestyle, nor does it demand excessive time devoted to maintaining my skin.

Last week, I made a point of visiting the renowned Collagen Art Exhibition. Standing before the light-and-shadow installations simulating protein folding, I suddenly realized: true anti-aging is not about resisting time, but about using technology to reprogram the algorithm of life.

recombinant short peptide

An innovative multifunctional collagen peptide solution that combines both anti-aging and anti-darkening effects.

Bifunctional plasmid

A unique fusion peptide design that integrates a melanin-inhibiting segment with a growth factor-mimicking segment, delivering both whitening and anti-aging effects.

Efficient Production System

Using the E. coli BL21 expression system with optimized cultivation processes, production costs are significantly reduced while yield is greatly increased.

Microneedle Delivery Technology

An innovative micrometer-scale microneedle delivery system that ensures active ingredients reach the dermis directly, enhancing absorption efficiency.

ChronoKolla - Technological Breakthroughs

Technological Breakthroughs and Industry Innovation

How ChronoKolla Redefines the Standard for Collagen Peptides

Regular Products
Single Effect
Premium Products
High Price
Our Engineered Product
Dual Effects · Scalable Production
Future Cost Reduction Potential
Dual-Effect Fusion Technology

Dual-Effect Intelligent Fusion Technology

Unified Biosynthesis

ChronoKolla Solution

A single solution that fulfills two needs: inhibiting melanin production and promoting collagen generation.

Single plasmid, single engineered culture product.

VS

Current Industry Status

The two needs of "melanin inhibition" and "anti-aging" are addressed by separate product categories, and simultaneous use may lead to ingredient incompatibility.

Production costs are high, as different components require extraction through distinct chemical and biological methods.

Precise
Action
Visible
Effect
Convenient & Low Risk
Market Medical
(Gold Micro-needle)
Topical
Skincare
Our Micro-needle Delivery System
Oral
Peptides
Microneedle Delivery System

Microneedle-based Delivery System

Precision Delivery

ChronoKolla Solution

Active ingredients are delivered directly to the dermis with high absorption efficiency.

Precise control over facial areas requiring aesthetic treatments enables accurate improvement of localized concerns.

Easy to operate, ready-to-use upon application, and relatively gentle.

VS

Current Industry Status

Although topical products are convenient to use, their results are not significant.

Although oral products are safe and effective, they are absorbed systemically.

Although aesthetic medical procedures deliver noticeable results, they are difficult to perform, time-consuming, labor-intensive, costly, and carry risks of skin damage.

Crafting Experiences
Perceptual Interface
Bodily Data
Public Participation
Exploring
BioArt Transdisciplinary Exhibition

BioArt Transdisciplinary Exhibition

Cost Optimization

ChronoKolla Solution

Crafting Experiences: The public participates in generating the exhibition through bodily data, transforming abstract concepts into embodied perception and sparking proactive reflection.

Provoking Inquiry: Technology becomes an invisible perceptual interface, constructing a cyclical experience connecting body, data, and imagery that points directly to philosophical foundations.

Integrating Sensations: We realize cross-sensory embodied experiences where data transforms into tangible light and shadow, exploring the poetic paradigm of "the body as interface."

VS

Current Industry Status

Unidirectional knowledge transmission leaves the public as passive recipients, creating a sense of distance.

There is a persistent reliance on static displays of technological spectacles or biological materials, framing the relationship as one of "viewing versus being viewed."

Data is mapped into on-screen graphics, separating visual from tactile experience and merely serving cognition.

Target Consumer Profiles

ChronoKolla’s Tailored Solutions for Four Core Consumer Groups

High-Pressure Knowledge Workers
💻
Typical Occupations
  • Internet Industry Professionals
  • Creative Industry Professionals
  • Finance / Consulting / Healthcare Professionals
⚠️
Core Pain Points
  • Chronic Fatigue and Stress
  • Skin Problems
  • Caffeine peptide segments neutralize stress hormones.
High-Intensity Athletes
🏃
Types
  • Endurance Sports
  • Strength Training
  • Outdoor Enthusiasts
⚠️
Core Pain Points
  • Damage from Extreme Environments
  • Skin Repair Needs
  • Photoprotective peptides + anti-inflammatory factors
Medical Aesthetic Consumers
💉
Typical Demographics
  • Basic Skincare Seekers
  • Anti-Aging Treatment Consumers
⚠️
Core Pain Points
  • Post-Procedure Recovery Care
  • Risk of Post-Procedure Hyperpigmentation
  • Specialized repair peptides inhibit post-procedure hyperpigmentation.
Populations Exposed to Special Environments
✈️
Typical Occupations
  • Flight Attendants
  • Healthcare Workers
  • Chemical Industry Workers
⚠️
Core Pain Points
  • Skin Sensitivity & Irritation
  • Accelerated Aging Issues
  • Barrier Repair Peptides + Antioxidants

Frequently Asked Questions (FAQ)

From a molecular structure perspective, the absorption of collagen peptides follows two pathways—the amino acid pathway (which aids in synthesizing proteins required by the human body) and the peptide pathway (where short peptide fragments such as dipeptides and tripeptides are absorbed). The smallest unit of protein is amino acids, which form peptide chains through various combinations, and these peptide chains then constitute proteins. As a type of protein, collagen also follows this principle. Thus, not all collagen peptides are broken down into amino acids before being reassembled.

In terms of application scenarios, besides oral collagen peptide products, topical collagen peptides are divided into collagen peptide dressings and collagen peptide microneedles. Through microneedles, collagen peptides can penetrate the stratum corneum and reach the dermis layer. Collagen peptide dressings have also been proven to have a certain degree of absorption effect. The general public lacks an in-depth understanding of collagen peptides and has limited channels to learn about their fundamental principles. Therefore, in addition to the main research and development planning of the project, we have also organized popular science lectures and installation exhibitions to address this.

video

Our Promotion Video

CAFA-Beijing: Recombinant Collagen Peptide and Novel Microneedles - ChronoKolla (2025) - Project Promotion [English]

Watch our video on iGEM.org

▶ Click to watch the full video on iGEM Video Platform