In modern society, polyamines are attracting growing attention for their diverse biological and industrial functions — from cell growth and anti-aging therapies to crop protection and biomaterial development. Yet, within this family lies a lesser-known but more powerful group: specialized polyamines.
These are long-chain and branched polyamines found mainly in plants and thermophilic microorganisms. Their unique structures give them remarkable stability and biological activity, making them highly promising for applications in:
a) Medicine – potential roles in anti-aging, neuroprotection, and tumor suppression
b) Agriculture – preserving agricultural products
c) Advanced Materials – serving as bio-based components for high-performance polymers
However, producing these molecules remains a major challenge. Traditional chemical synthesis suffers from low yield and high cost, while natural extraction offers only trace amounts.
This is where synthetic biology comes in：Our project aims to develop a thermotolerant microbial chassis capable of efficiently synthesizing specialized polyamines. By exploring heat-adapted microorganisms and decoding their stress-resistance mechanisms, we are building the foundation for a new biomanufacturing strategy — one that transforms rare bioactive molecules into accessible, sustainable, and industrially useful compounds.
