Peristaltic Pump:Simulate GI fluid, replace animal tests
Intestinal Microorganism Movement Simulation Device: Cost-Effective and Pioneering Probiotic Research
In the vast realm of human health research, the crucial role of intestinal microorganisms, especially probiotics, in maintaining body balance and absorbing and metabolizing abnormal substances, has become a focal point in the scientific research community. Our self-developed intestinal microorganism movement simulation device, which focuses on the absorption of xanthine and hypoxanthine by probiotics, provides a cutting-edge research tool for exploring the connection between intestinal microorganisms and human health. Moreover, it stands out with its exceptional cost-effectiveness.
Cost Comparison: Breaking the High-Price Barrier
At present, similar products on the market are extremely expensive. A basic set of intestinal microorganism simulation equipment can easily cost over 500,000 yuan. The core component of these products—the pump used for precisely controlling the circulation of simulated intestinal fluid—often exceeds 10,000 yuan per unit. Such exorbitant prices have deterred many research institutions and enterprises from making purchases, severely limiting the widespread conduct of relevant research.
In contrast, our intestinal microorganism movement simulation device adopts the highly cost-effective BT100J-1A peristaltic pump. This pump boasts excellent performance, featuring a rotation speed range of 0.1 - 100 rpm, reversible rotation in both directions, and a rotation speed resolution of 0.1 rpm, among other advantages. Priced at only around 2,000 - 3,000 yuan, our entire device significantly reduces costs while ensuring equal or even superior performance, achieving true value for money.
Core Architecture:Ingenious Design and Cost-Effectiveness
Our device is centered around a core architecture consisting of two 2-ml syringes and specially designed connecting pipelines. The syringes are filled with a mixture of self-developed YES302 probiotics and hydrogel. The hydrogel creates a stable "habitat" for the probiotics, accurately simulating the colonization environment in the intestines. The YES302 probiotics have unique metabolic characteristics, specifically targeting the absorption of xanthine and hypoxanthine, and hold great potential in maintaining human health. This ingenious design not only ensures experimental effectiveness but also substantially reduces material costs.
Flexible Adaptation: Customized Selection to Minimize Waste
We have made innovative optimizations in the storage of simulated intestinal fluid. Previous products often used fixed large-capacity containers, resulting in significant waste of simulated intestinal fluid. Our device, with an upgraded pump system, allows for the flexible selection of small bottles of different sizes to store the simulated intestinal fluid according to experimental requirements. This not only facilitates operation but also effectively reduces the amount of simulated intestinal fluid used, further lowering experimental costs. The BT100J-1A peristaltic pump plays a crucial role in this regard, as its precise flow control function, with a flow range of 0.0002 - 380 ml/min (single tube), can meet the precise requirements for the flow rate of simulated intestinal fluid in different experimental scenarios.
Magnetic Fixation: Stable and Efficient, Saving Resources
To optimize the fixation effect of the probiotics, we have added magnetic beads to the hydrogel and adjusted the ratio of hydrogel, magnetic beads, and probiotic solution to 4:1:5. Simultaneously, a magnet is placed under the syringe to fix the hydrogel using magnetic force. Compared to the complex and expensive fixation systems of other products, our magnetic fixation solution is cost-effective and easy to operate, significantly saving costs while ensuring the stability of the experimental environment.
Precise Control: Convenient and Controllable, Reducing Losses
The device achieves the circulation of simulated intestinal fluid through the BT100J-1A peristaltic pump. Operators can flexibly adjust the pump's parameters using membrane keys to precisely control the flow rate, volume, and circulation mode of the simulated intestinal fluid, simulating the intestinal environment under different physiological conditions. This precise control prevents experimental failures and material waste caused by inaccurate parameters, reducing the overall experimental costs. Moreover, the pump has a power-failure memory function, which allows it to resume work according to the state before the power failure when reconnected to the power supply, further enhancing the convenience and stability of the experiment.
Easy Maintenance: User-Friendly and Labor-Saving
The various components of the device are reasonably designed, making them easy to disassemble, replace, and clean, which reduces the time and labor costs associated with device maintenance. The BT100J-1A peristaltic pump also shares this advantage. Its simple structure makes maintenance easy, and users can perform some basic maintenance tasks themselves, such as loosening the pressing block on the hose to prevent deformation and cleaning and drying the rollers. Compared to the complex maintenance procedures and high maintenance costs of other products, our device is more cost-effective during use.
Room for Improvement: Continuous Optimization for Enhanced Cost-Effectiveness
Although our device already offers numerous advantages, we are not satisfied with the status quo. We are actively researching and developing improvement plans to address issues related to device stability, data monitoring and analysis, versatility and scalability, as well as cost and sustainability. For example, we aim to develop a more stable magnetic fixation system, introduce advanced real-time monitoring technologies, optimize the device design to enhance versatility and scalability, and find more cost-effective and sustainable alternative materials. These improvement measures will further enhance the cost-effectiveness of the device and provide stronger support for scientific research.
This intestinal microorganism movement simulation device, with its outstanding cost-effectiveness and excellent performance, provides a crucial platform for our in-depth research on the mechanism of YES302 probiotics in absorbing xanthine and hypoxanthine. Choosing our device means opting for a cost-effective scientific research solution. Let us join hands to promote the integration and development of intestinal microorganism research and human health, and propel relevant research to new heights!
UriGuard: AI Voice Assistant for Hyperuricemia Management
We constructed UriGuard—an AI voice interaction assistant specifically designed for hyperuricemia management—using commonly available electronic components on the market. With the core positioning of "providing personalized, accessible health support for hyperuricemia patients", UriGuard integrates functions such as dietary purine calculation, medication dosage guidance, and disease prevention education. It solves the pain points of traditional health management (e.g.cumbersome manual calculation of purine intake, difficulty in obtaining real-time medication advice) and becomes a "portable health butler" for patients.
UriGuard's hardware system is built around "high performance, strong adaptability, and user-friendly experience", with each component carefully selected to match the actual needs of hyperuricemia patients (e.g. elderly patients' visual and auditory needs, outdoor usage scenarios). The specific composition and design logic are as follows:
UriGuard does not only realize basic voice interaction but also deeply integrates the "intestinal purine-serum uric acid dynamic model" (developed in the GoutBuster project) to provide professional and personalized services:
1.Dietary Purine Intelligent Calculation: Through natural language processing technology, it converts patients' voice input of food information (e.g."I ate a bowl of pork rib soup today") into purine intake data by connecting to the official database of China Food Network. It can accurately calculate the specific content of xanthine and hypoxanthine in the food and prompt whether the intake exceeds the daily recommended amount (200mg for hyperuricemia patients).
2.Personalized Medication Dosage Guidance: By embedding the "intestinal purine-serum uric acid dynamic model", it combines the patient's daily purine intake (calculated from diet) and personal characteristics (age, gender, weight) to automatically generate the daily personalized intake of probiotic drugs (e.g.YES302/YES303), avoiding the risk of incorrect dosage caused by manual calculation.
3.Disease Prevention Science Popularization: It provides targeted science content for hyperuricemia, such as "the relationship between alcohol and uric acid elevation" and "correct way to hydrate for gout prevention". Patients can obtain knowledge by voice commands (e.g."Tell me how to prevent gout attacks"), and the content is presented in a concise and easy-to-understand language (avoiding professional jargon) to improve acceptance.
4.The multi-language function supports real-time switching among multiple languages such as Chinese, English, French and Spanish, meeting the usage needs of patients of different nationalities and ensuring the applicability of functions like dietary purine calculation and medication guidance across the globe.
These are some typical usage scenarios of UriGuard:
1. Home Dietary Management: When preparing meals, patients can ask UriGuard, "How much purine is in 200g of freshwater fish?" to quickly decide whether to include the food in the recipe, helping to control daily purine intake from the source.
2. Outdoor Dining & Shopping: When dining out or buying groceries, patients can use the 4G function of the ML307R module to inquire, "Is it suitable for me to eat hot pot?" The assistant will combine common hot pot ingredients (e.g.beef rolls, mushrooms) to analyze purine content and give suggestions, solving the problem of "daring not to eat out" due to unclear purine information.
3. Elderly Patient Independent Use: Elderly patients can operate UriGuard without relying on family members—they only need to press the wake-up button and speak commands, and the large screen and loud volume ensure they can obtain information independently, enhancing their sense of autonomy in health management.
UriGuard's value lies in "connecting professional medical resources with daily patient needs" through hardware innovation:
1. Improving Management Convenience: It simplifies the complex process of "dietary recording → purine calculation → medication adjustment" into one-click voice interaction, reducing the time cost of patient health management (from 30 minutes of manual calculation to 1 minute of voice inquiry).
2. Enhancing Treatment Compliance: By providing real-time, personalized guidance, it helps patients form a regular dietary and medication habit. For example, it can send timed reminders such as "It's time to take probiotic drugs today" to improve the adherence rate of long-term treatment.
3. Expanding Health Equity: For patients in remote areas with limited access to medical resources, UriGuard can transmit local dietary data to the cloud and obtain professional advice from experts, narrowing the gap in health management services between urban and rural areas.
In line with the GoutBuster project's concept of "developing accessible and safe hyperuricemia treatment solutions", UriGuard turns laboratory research achievements (e.g.dynamic models, purine databases) into tangible hardware products, truly promoting the transformation of scientific innovation into practical public health benefits.
To facilitate other teams in replicating our hardware, the assembly method of this voice assistant is as follows:
Gastrointestinal Simulation Model:Anime-style, show probiotics work
We created an anatomical diagram of the digestive system using anime-style illustrations, and printed anime character designs of xanthine/hypoxanthine and GoutBuster on cardboard. Together, these components form a demonstration model illustrating the mechanism of action of the engineered bacteria.
This model accurately shows how our engineered bacteria enter the stomach via food or other carriers, then move to the small intestine through gastric peristalsis and chyme propulsion. It visualizes the movement trajectory of the bacteria within the digestive system, allowing viewers to intuitively observe the complete process from entry into the body to arrival at the site of action.
Meanwhile, the vivid diagrams help us explain the complex metabolic process in which excess xanthine/hypoxanthine is recognized, bound, and transported by the engineered bacteria. This enables viewers to clearly understand the interaction between the engineered bacteria and purine compounds, as well as the underlying mechanisms of their transport and processing.
When this demonstration model is used in popular science lectures by our HP team—especially for young children—it effectively sparks their interest and curiosity in scientific knowledge. Through the anime-style presentation, complex biological concepts are transformed into easy-to-understand visual language, lowering the learning barrier. As children observe the model, they naturally raise questions and get answers through interaction, creating an educational and entertaining learning experience. Additionally, this vivid demonstration method helps deepen viewers' memory of key knowledge points, making the impact of popular science lectures more lasting and significant.