Without YES302
Hyperuricemia is a metabolic disorder caused by abnormal purine metabolism, resulting in an excessive concentration of uric acid in the blood (for adult males / post-menopausal women ≥ 420 μmol/L, pre-menopausal women ≥ 360 μmol/L).
We often eat
food high in
purine...
But
we've got
a new idea!
But
we've got
a new idea!
XANTHINE:
Xanthine (from Ancient Greek ξανθός xanthós 'yellow‘ for its yellowish-white
appearance) is a purine base found in most human body tissues and fluids, as well as in other organisms.
Several stimulants are derived from xanthine, including caffeine, theophylline, and theobromine.
HYPOXANTHINE:
Hypoxanthine is a naturally occurring purine derivative. It is occasionally found
as a constituent of nucleic acids, where it is present in the anticodon of tRNA in the form of its nucleoside
inosine. More frequently in purine degradation, xanthine is formed from oxidation of hypoxanthine by xanthine
oxidoreductase.
URIC ACID:
Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with
the formula C5H4N4O3. It forms ions and salts known as urates and acid urates, such as ammonium acid urate.
Uric acid is a product of the metabolic breakdown of purine nucleotides, and it is a normal component of
urine. High blood concentrations of uric acid can lead to gout and are associated with other medical
conditions, including diabetes and the formation of ammonium acid urate kidney stones.
YES302:
YES302 is an antibiotic-sensitive engineered probiotic strain capable of high-efficiency
xanthine transport. Its genome features a scarless deletion of the asd gene, while harboring a recombinant
plasmid carrying a mutated XanQ transporter, a mutated UacT transporter, and the asd gene. This strain
achieves 90% efficient xanthine uptake to reduce both xanthine and uric acid concentrations in reaction
systems, offering a safe and sustainable microbial preventive therapy for the treatment of hyperuricemia.
Based on the safe probiotics, we have developed the YES series of engineered probiotics - they can precisely reach the intestines. While competing to absorb the precursors of purine and preventing them from being converted into uric acid; they also secrete uricase to directly degrade the uric acid already formed in the intestines. The entire process is completed locally in the intestines, without any systemic side effects, and meets the "safe and efficient" treatment requirements.
