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Description

LOGIC (Lasting Optimized Genetic Input Calculator)

Biological computing holds great promise for the future, yet past engineered bacterial circuits for logic gates have suffered from excessive complexity, cumbersome operation, and reliance on multiple input substances. Our LOGIC project overcomes these problems by developing a novel approach to constructing a biocomputer—utilizing quorum sensing and spatial diffusion to form logic gates. For addition calculation, we construct high-pass and band-pass genetic circuits based on the quorum sensing (QS) system. Through the diffusion of QS molecules in solid media, we can build various logic gates and connect them to perform multi-bit binary calculations. For repetitive operation, we engineer a photo-induced QS molecule degradation enzyme by predicting, simulating and adding domains to refresh the calculator. Based on the calculator, we can also build accessories like result storage, decimal result display and latches, demonstrating its extensive prospects. Furthermore, we construct a LOGIC Toolkit with a visualization software for future researches.

Essential First Steps

Familiarize yourself with the official iGEM competition rules, policies, and judging criteria:

  • Carefully review the Wiki Requirements page to ensure your wiki meets all necessary standards for judging and awards.
  • Understand the criteria and required wiki pages for Gold, Silver, and Bronze Medals on the Medals page.
  • Explore the various Project Prizes and their corresponding wiki requirements on the Project Prizes Page.
  • Discover the eligibility criteria and wiki requirements for Special Prizes on the Special Prizes Page.

Building Your Wiki

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  • Document Early & Often: Start documenting your project from day one. Don't wait until the Wiki Freeze.
  • Prepare for Deadlines: Stay up-to-date with important deadlines and events by checking the iGEM Competition Calendar.

Tips for Success

  • Clearly Define Your Project: Explain your project's goals, methodology, and expected outcomes in a clear and concise manner.
  • Show Your Progress: Regularly update your wiki with your team's progress, experiments, and results.
  • Engage Your Audience: Consider your global audience and use language that is accessible to everyone.
  • Human Practices & Safety: Thoroughly document your team's human practices activities and safety considerations.
  • Collaborate & Share: Highlight collaborations with other teams and institutions.
  • Have Fun and Learn! iGEM is a unique opportunity to learn, grow, and contribute to synthetic biology.

Inspiration

You can also view other team wikis for inspiration! Here are some examples: