Description

I. Project Overview

We deliver tiered, evidence-based synbio education that links classroom learning with frontline needs. 2025 focuses on cancer literacy and standardized prevention for seniors and youth, while co-creating open resources with global iGEM teams.

II. Educational Approach

1) Tiered System

Basic (K-12): playful experiments and concept games to seed interest.
Higher Ed: project-based labs, data analysis, and research thinking.

2) Semi-Structured Clinical Interviews (Class-A Hospital)

We pair literature scans with semi-structured interviews to anchor education in real clinical scenarios and patient education gaps.

Interview · Dr. Qin: Priorities for patient literacy and standardized prevention.

Interview · Dr. Li: Cross-validating topics and refining our teaching checklist.

3) Background Scoping & Need Fixing

We framed indicators “global → China → regional → hospital” to finalize the education scope and metrics.

Scoping Document: Evidence triage pipeline used to lock background and target audience.

III. Collaboration Network

We collaborate with universities, research institutes, and iGEM teams to co-develop curricula, exchange materials, and broaden impact.

Handbook Co-Creation (1/2): Multi-team topic mapping and copy polishing.

Handbook Co-Creation (2/2): Case studies and classroom-ready worksheets.

Handbook Preview

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Timeline

IV. Educational Resources

Open, reusable resources for different audiences: co-authored handbook, 4K lab videos, and SOP libraries. We keep a reproducible archive (people-machine-material-method-environment) for traceability.

4K Dual-Camera Recording: Step-by-step operations captured for reproducibility.

Popularization Channels

We run a “deep popularization + team profile” format on WeChat; Bilibili series supplements video-first learning.

WeChat: Long-form explainers and team stories for the public.

V. Team & Advisors

Guided by two domain experts, we iterate from problem discovery → pathway design → safety & quality → translation & communication. Below is an interview-backed summary (wide table on desktop, card layout on mobile).

Advisor	Affiliation / Expertise	Key Guidance	Representative Quote	Direct Impact on Our Roadmap
Prof. Nan Wang Marine microbial natural products & biosynthesis	Zhejiang University (ZJU) Methodology & route selection	Problem-first: define target users & clinical pain points, then back-cast modules. Modular “plug-and-play” pathways for rapid recombination/optimization. Verifiability: quantitative, reproducible readouts per step (expression/function/safety). Use semi-structured clinical interviews to reality-check assumptions.	“Bind functional molecules and engineered pathways to a concrete disease scenario with measurable readouts—depth and real-world value must advance together.”	Added KPI sheets per module for go/stop decisions. Restructured design into swappable enzyme/pathway blocks. Embedded hospital interviews as a gating step before milestones.
Dr. Jinzhong Xu Marine fungal natural products & quality control	Chinese Academy of Sciences (Marine) QC, scale-up, risk governance	End-to-end QC: strain characterization, expression stability, batch consistency, impurity profile. Move scale-up & cost constraints into early design. Safety by design: biosafety level, resistance/environmental release, ethics compliance. Align bench metrics with clinically relevant readouts; prepare public-facing summaries.	“Beyond ‘can we make it’, always ask: is it stable, how to scale, and how to meet standards.”	Established a QC panel and release criteria per build. Introduced pilot-scale checks and cost accounting to design dossiers. Added biosafety & ethics checklists; strengthened outreach messaging.

Prof. Nan Wang

Zhejiang University (ZJU) · Marine microbial natural products & biosynthesis

Key Guidance

• Problem-first; back-cast modules from clinical pain points.
• Modular “plug-and-play” pathways; verifiable, quantitative readouts.
• Use semi-structured clinical interviews to validate assumptions.

Representative Quote

“Bind functional molecules and engineered pathways to a concrete disease scenario with measurable readouts.”

Direct Impact

• KPI sheets per module.
• Swappable enzyme/pathway blocks.
• Hospital interviews as milestone gates.

Dr. Jinzhong Xu

CAS (Marine) · Marine fungal natural products & quality control

Key Guidance

• End-to-end QC; batch consistency and impurity profile.
• Consider scale-up & cost early in design.
• Safety by design; biosafety and ethics compliance.

Representative Quote

“Beyond ‘can we make it’, ask: is it stable, how to scale, and how to meet standards.”

Direct Impact

• QC panel & release criteria per build.
• Pilot-scale checks and cost tracking.
• Biosafety/ethics checklists + public summaries.

VI. Impact & Outlook

Our programs reach diverse groups across cities and schools, raising synbio literacy and illustrating research-to-society pathways.

Creative Outreach: SYPHU puzzle-logo merchandise used in sharing sessions to boost engagement.

VII. Acknowledgements & References

We thank partnering hospitals, universities, and iGEM teams for interviews, co-editing, and dissemination. A concise reference list will be maintained here as materials evolve.