Ginseng, known as the “King of Herbs”, is a precious medicinal plant which is widely used in clinical practice.
Rare ginsenoside Rh1 is one of the terpenoids with significant pharmacological activity in ginseng.
However, the traditional methods for obtaining Rh1 mainly involve plant extraction and chemical synthesis. The very low output of Rh1 in these methods lead to high price of the Rh1-based cosmetics and heavy environmental burden.
We dive into the sea and find new raw materials.
We find that the global biomass of marine algae reached 35 million tons, especially in China. This demonstrates its strong potential as a promising fermentation substrate.
In addition, galactose from hydrolysate is an advantageous carbon source for terpenoid production inhibit Saccharomyces cerevisiae, an optimal chassis cell with MVA pathways , as it avoids the Crabtree effect.
Module 1: Red Algae Utilization
Module 2: MVA pathway regulation
Module 3: Rare ginsenoside Rh1 Synthesis
We achieve the sustainable production of Rh1 by engineering Saccharomyces cerevisiae
to utilize red algae as the carbon source.
We propose the development of a skincare line designated “GRACE” that is formulated with ginsenoside Rh1 biosynthesized by metabolically engineered Saccharomyces cerevisiae. GRACE offers high-quality skincare formulas with affordability, empowering more people to experience luxury-grade results.
Let algae yield, no forests fall.
GRACE we craft, accesible for all.
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